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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 941515, 6 pages
http://dx.doi.org/10.1155/2011/941515
Research Article

Association of Angiotensin-Converting Enzyme Intron 16 Insertion/Deletion and Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Preeclampsia in South East of Iran

1Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Received 26 February 2011; Accepted 4 June 2011

Academic Editor: Saulius Butenas

Copyright © 2011 Saeedeh Salimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Some evidence suggests that a variety of genetic factors contributed in pathogenesis of the preeclampsia. The aim of this study was to assess the association between the angiotensin-converting enzyme (ACE) I/D and angiotensin II type1 receptor A1166C polymorphisms with preeclampsia. This study was performed in 125 preeclamptic pregnant women and 132 controls. The I/D Polymorphism of the ACE gene was assessed by polymerase chain reaction and the A1166C Polymorphism of the AT1R gene was determined by restriction fragment length polymorphism. The genotype and allele frequencies of I/D polymorphism differed between two groups. The risk of preeclampsia was 3.2-fold in pregnant women with D allele (OR, 3.2 [95% CI, 1.1 to 3.8]; ). The distribution of the AT1R gene A1166C polymorphism was similar in affected and control groups. Our results supported that presence of the I/D polymorphism of ACE gene is a marker for the increased risk of preeclampsia.