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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 954602, 8 pages
Cytotoxic CD4 T Cells in Antiviral Immunity
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Received 2 July 2011; Accepted 9 September 2011
Academic Editor: Julie Curtsinger
Copyright © 2011 Nikki B. Marshall and Susan L. Swain. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [58 citations]
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- Alexander W. Boyden, Kevin L. Legge, and Thomas J. Waldschmidt, “Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses,” Plos One, vol. 7, no. 7, 2012.
- M. Fang, N. A. Siciliano, A. R. Hersperger, F. Roscoe, A. Hu, X. Ma, A. R. Shamsedeen, L. C. Eisenlohr, and L. J. Sigal, “Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection,” Proceedings of the National Academy of Sciences, vol. 109, no. 25, pp. 9983–9988, 2012.
- L S Cauley, and L Lefrançois, “Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells,” Mucosal Immunology, vol. 6, no. 1, pp. 14–23, 2012.
- Martina Perše, and Anton Cerar, “Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks,” Journal of Biomedicine and Biotechnology, vol. 2012, pp. 1–13, 2012.
- Alice O. Kamphorst, “CD4 T-cell immunotherapy for chronic viral infections and cancer,” Immunotherapy, vol. 5, no. 9, pp. 975–987, 2013.
- Diane Goéré, Nathalie Chaput, Laurence Zitvogel, Caroline Flament, Sylvie Rusakiewicz, Vichnou-Colame Poirier, Oliver Kepp, Isabelle Martins, Julien Pesquet, Alexander Eggermont, and Dominique Elias, “Potent immunomodulatory effects of the trifunctional antibody catumaxomab,” Cancer Research, vol. 73, no. 15, pp. 4663–4673, 2013.
- Tara M. Strutt, K. Kai McKinstry, Nikki B. Marshall, Allen M. Vong, Richard W. Dutton, and Susan L. Swain, “ Multipronged CD4 + T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus ,” Immunological Reviews, vol. 255, no. 1, pp. 149–164, 2013.
- Cherie T. Ng, Laura M. Snell, David G. Brooks, and Michael B.A. Oldstone, “Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections,” Cell Host & Microbe, vol. 13, no. 6, pp. 652–664, 2013.
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- Kong Chen, and Jay K. Kolls, “T Cell–Mediated Host Immune Defenses in the Lung,” Annual Review of Immunology, vol. 31, no. 1, pp. 605–633, 2013.
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- Anna L Furmanski, Ryan F L O'Shaughnessy, Jose Ignacio Saldana, Michael P Blundell, Adrian J Thrasher, Neil J Sebire, E Graham Davies, and Tessa Crompton, “T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss,” Journal of Investigative Dermatology, vol. 133, no. 5, pp. 1221–1230, 2013.
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