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969618.fig.002b
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Figure 2: Schematic of commonly employed surgical mouse models of human disease. (a) The dorsal skin fold chamber allows real-time imaging of cutaneous physiology in high resolution when combined with intravital microscopy techniques (right). (b) Parabiotic models permit researchers to investigate the role of circulating factors and/or cells from the donor parabiont in cutaneous wound repair. (c) Engineered human skin constructs can be grafted onto immunocompromised mice to study human skin explant physiology within a living biologic (immunodeficient) environment.