Review Article
Surgical Approaches to Create Murine Models of Human Wound Healing
Table 1
Major differences between mouse and human skin.
| | Mouse | Human |
| Hair cycle | Approximately 3 weeks | Highly variable, region-dependent | Epithelial architecture | No rete ridges | Rete ridges present | Apocrine sweat glands | Not present in skin, extensive in mammary glands | Present in axilla, inguinal, and perianal skin regions | Biomechanical properties | Thin, compliant, loose | Thick, relatively stiff, adherent to underlying tissues | Hypodermal thickness | Hair cycle-dependent | Less variable | Subcutaneous muscle layer | Present throughout as panniculosus carnosus | Present only in neck region as platysma | Major method of wound healing | Contraction | Granulation tissue formation and re-epithelialization |
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