Table 1: Major differences between mouse and human skin.

MouseHuman

Hair cycleApproximately 3 weeksHighly variable, region-dependent
Epithelial architectureNo rete ridgesRete ridges present
Apocrine sweat glandsNot present in skin, extensive in mammary glandsPresent in axilla, inguinal, and perianal skin regions
Biomechanical propertiesThin, compliant, looseThick, relatively stiff, adherent to underlying tissues
Hypodermal thicknessHair cycle-dependentLess variable
Subcutaneous muscle layerPresent throughout as panniculosus carnosusPresent only in neck region as platysma
Major method of wound healingContractionGranulation tissue formation and re-epithelialization