The Tale of Protein Lysine Acetylation in the Cytoplasm

Figure 1

Schematic overview of cytoplasmic mechanisms regulated by acetylation. (a) Localisation of acetylation events within a cell. Indicated are individual acetylated proteins and cytoskeletal structures (cortical actin and actin stress fibers, microtubules, intermediate filaments) as well as organelles (nucleus, mitochondria, ER, ERGIC, golgi) in which acetylation and deacetylation events take place. (b) Involvement of reversible acetylation in the regulation of various cytoplasmic processes, including cell migration following cytoskeleton remodelling, individual protein transport as well as vesicular transport and nucleocytoplasmic shuttling of proteins. (c) Regulation of stress response and cytoplasmic cleanup systems by various acetylation/deacetylation events.