Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine: Vaccinia Tiantan Strain

Table 1

Neutralizing antibody titer from different time points after VTT vaccination and MVTT-S Challenges.

Groups	i.m.		i.n.		i.o.		s.c.		placebo
Vaccination
VTT (3 weeks); VTT (6 months)	NA; NA	428; 671	NA; NA	711; 2265	NA; NA	2370; 2397	NA; NA	32; 387	NA; NA	ND; ND
MVTT-S Challenge
i.m. (1st); i.m. (2nd); i.n. (1st); i.n. (2nd); i.o. (1st); i.o. (2nd)	ND; 2732; ND; ND; ND; ND	3288; 6280; 2065; 1587; 4555; 2362	ND; 9369; ND; ND; ND; ND	5249; 5210; 5141; 2944; 4937; 5148	ND; 936; ND; ND; ND; ND	4742; 4721; 6838; 6205; 2601; 4901	ND; 1598; ND; 1026; ND; 2710	333; 1386; 520; 350; 35; 221	ND; 14261; ND; 8251; ND; 21523	46; 718; 349; 1004; 101; 1014

The values of anti-S IC₅₀ are in bold whereas the values of anti-VTT IC₅₀ are not. NA: not applied; ND: not detected.