Table 1: Quantitative data between control (wild-type) and dystrophic (mdx) TA muscles without and with injury. Except for RD, all the calculated water diffusion characteristics were significantly altered () after injury, and to a greater extent in mdx muscles. There was a trend toward increased RD, but this was not significant (NS) at .
mdx noninjured versus wt noninjured
wt injured versus noninjured
mdx injured versus wt injured
mdx injured versus noninjured
Whole MD (mm2/s)
NS
NS
versus )
versus )
Proximal MD (mm2/s)
NS
NS
versus )
NS
Middle MD (mm2/s)
NS
NS
versus )
NS
Distal MD (mm2/s)
NS
NS
NS
NS
Whole AD (mm2/s)
NS
NS
versus )
versus )
Proximal AD (mm2/s)
NS
NS
versus )
versus )
Middle AD (mm2/s)
NS
NS
versus )
versus )
Distal AD (mm2/s)
NS
NS
NS
NS
Whole FA
NS
NS
versus )
versus )
Proximal FA
NS
NS
versus )
versus )
Middle FA
NS
NS
versus )
versus )
Distal FA
NS
NS
NS
NS
Whole RD (mm2/s)
NS
NS
NS
NS
Proximal RD (mm2/s)
NS
NS
NS
NS
Middle RD (mm2/s)
NS
NS
NS
NS
Distal RD (mm2/s)
NS
NS
NS
NS
Whole T2 (ms)
NS
NS
NS
NS
Proximal T2 (ms)
NS
NS
versus )
NS
Middle T2 (ms)
NS
NS
NS
NS
Distal T2 (ms)
NS
NS
NS
NS
Explanation of DTI parameters (apply to all but the last 4 lines, which report data for T2): MD: mean diffusivity; measure of total diffusion within a voxel; AD: axial diffusivity; diffusion along the longitudinal axis; FA: fractional anisotropy; the fraction of unidirectional diffusion; RD: radial diffusivity; diffusion occurring perpendicular to a track; T2: a time constant describing the exponential decay of signal.