Regulation of Epithelial Sodium Transport via Epithelial Na⁺ Channel

Figure 1

Regulatory pathways of ENaC and nonselective (NSC) channel in renal and fetal alveolar type II epithelial cells. Arrow lines without (+) mean the conversion to a form at the end point of arrow form a form at the starting point of arrow. Arrow lines with (+) mean that the compound at the starting point of arrow; (1) stimulates the conversion indicated by an arrow without (+), (2) activates an enzyme, or (3) induces the indicated condition. Arrowheads with dashed lines mean that the compound at the start point of the arrowhead with dashed line moves to the end point of the arrowhead with dashed line (translocation). [Cl^-] is the concentration of cytosolic Cl^-. Circled P means a phosphorylated form.