Two polar morphologic forms are representative of histological findings in lupus nephritis. (a) DPLN shows diffuse hypercellularity of endothelial cells and mesangial cells throughout the glomerulus. Peripheral capillary are thickened by subendothelial deposition of immune complex (x400, PAS staining). (b) On the other hand MLN shows generalized diffuse thickening of the peripheral capillary walls without prominent hypercellularity in the glomerulus (x400, PAS staining). (c) Glomerular IgG subclass deposits in a patient with MLN determined by immunofluorescence microscopy (x100). IgG subclass deposition was examined using FITC-conjugated mouse antihuman IgG subclass specific mAbs.
