MRL/lpr mice disrupted the WSX-1 gene developed disease essentially identical with human MLN. (a) A representative glomerulus of 36-week-old WSX-1−/− MRL/lpr mouse (x400, PAM staining). Arrows indicate spike formation. (b) Electron micrograph (x4000) of the glomerular capillary of the mouse shows numerous subepithelial electron-dense deposits in the basement membrane (arrows).
