Table 1: ZEBOV protein sequences recognized by murine CD8+ T cells. The table is adapted and expanded from [97].

ZEBOV proteinEpitope sequenceAmino acid positionRestrictionProtectiveaReference

GlycoproteinVSTGTGPGAGDFAFHK141–155H-2dYes[96, 98]
LYDRLASTVI161–169H-2dNT[25, 86, 98]
EYLFEVDNL231–239H-2dNT[25, 98]
WIPYFGPAAEGIYTE531–545H-2bNo[86, 96]
TELRTFSI577–584H-2kNT[99]

NucleoproteinVYQVNNLEEIC44–52H-2bYes[37, 96, 100]
GQFLFASL148–156H-2bYes[96]
FLSFASLFL150–159HLA-A2.1NT[101]
RLMRTNFLI202–210HLA-A2.1NT[101]
SFKAALSSLA279–287H-2dYes[96, 100]
FQQTNAMVT388–396H-2bNT[100]
KLTEAITAA404–412HLA-A2.1NT[101]
DAVLYYHMM663–671H-2bYes[96]

VP24KFINKLDALH159–168H-2dYes
NYNGLLSSI171–179H-2dYes[96]
PGPAKFSLL214–222H-2dYes

VP30KFSKSQLSLLCETHLR181–196H-2dYes
H-2bYes
DLQSLIMFITAFLNI231–245H-2dYes[96]
H-2bYes

VP35CDIENNPGL45–53H-2bYes
MVAKYDHL138–145H-2bYes
TVPQSVREAFNNL190–202H-2dYes[96]
RNIMYDHL225–323H-2bYes
PGFGTAFHQLVQVICK233–248H-2dYes

VP40LRIGNQAFLQEFVLPP150–165H-2bYes[86, 96]
AFLQEFVLPPVQLPQ160–175H-2dYes[96]
YFTFDLTALK171–180H-2dYes[86, 96]
TESPEKIQAI232–241H-2dYes[86, 96]

aProtection from lethal challenge demonstrated by either peptide vaccination or by adoptive transfer experiments (Yes, >50% protection observed).
NT: Not tested.