Novel Image Analysis Approach Quantifies Morphological Characteristics of 3D Breast Culture Acini with Varying Metastatic Potentials

Table 2

Discriminative influence of the proposed features based on the F-score values.

Feature label	F-Score	Rank
Number of nuclei within the acinar structure	0.0547	14
Elongation of the acinar structure	0.1122	6
Ratio between the hollow lumen and acinar structure areas	0.1602	4
Internal integrin 𝛼6 Density	0.1205	5
Density of integrin 𝛼6 inside the 30% circle	0.0620	11
Density of integrin 𝛼6 inside the 40% circle	0.0611	12
Density of integrin 𝛼6 inside the 50% circle	0.0885	9
Density of integrin 𝛼6 inside the 60% circle	0.0953	8
Density of integrin 𝛼6 inside the 70% circle	0.0598	13
Continuity of integrin 𝛼6 along the basal membrane	0.5725	1
Amount of integrin 𝛼6 colocalized with integrin 𝛼3	0.0337	15
Continuity of integrin 𝛼3 along the basal membrane	0.1046	7
Total integrin 𝛼3 density	0.2651	3
Amount of integrin 𝛼3 colocalized with integrin 𝛼6	0.3526	2
Density of integrin 𝛼3 in the exterior of the hollow lumen	0.0716	10