A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology
Figure 2
Masson’s trichrome of the left common carotid arteries (a) and the right common carotid arteries at 8 weeks (b) and at 12 weeks ((c) and (d)) after injury. Panels (a) and (b) were derived from the same rabbit. Panel (d) was a higher magnification taken from the black box in Panel (c) and shows a forming fibrous cap over a lipid core. The collagen content was significantly higher at 8 weeks (b) after injury than at 12 weeks (c) after injury. The plaques of this model are characterized by an obvious lipid core with an overlaying fibrous cap ((b), (c), and (d)). No evident atherosclerosis was seen in the left common carotid artery (a). original magnification, ×40 ((a)–(c)) and ×100 (d).
