Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus

Table 2

The IC₅₀ values of isolated compounds towards various cell lines.

Cell line	IC50 (μg/mL)
	(1)	(2)	(3)	Doxorubicin
HL60	2±0.7	26±0.8	17±0.8	0.2±0.03
K562	0.5±0.05	>30	>30	nt
MCF7	5±1.2	27±1.9	23±1.3	0.2±0.06
HeLa	8±3.3	nt	nt	nt
MDA-MB 231	12±1.1	nt	nt	nt
HT29	14±1.5	nt	nt	nt
HepG2	20±2.0	nt	nt	nt
3T3	7±1.6	nt	nt	nt
MCF10	>30	nt	nt	nt
PBMC	>30	nt	nt	>30

Note: (nt)-not tested, (1)-pyranocycloartobiloxanthone A, (2)-dihydroartoindonesianin C, and (3)-pyranocycloartobiloxanthone B. Data represent mean ± SD of triplicate determinations from three independent experiments.