Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
Figure 1
Baseline torque before large-strain injury. Maximum isometric tetanic torque of the dorsiflexor muscle group was measured prior to LSI. All control strains (A/WySnJ, C57Bl/6J, SWR/J, and C57Bl10/J) produced a similar level of contractile torque. Among the Dysf mutants, only SJL/J mice and B10.SJL mice were weaker than their corresponding controls. SJL/J mice were also weaker than A/J mice. Raw torque produced by DMDmdx was the highest among the studied strains of mice. *Significant difference compared to control strain at same time point. NS:no significant difference. ‡Significant difference compared to A/J at same time point.
