Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy

Figure 2

Torque after LSI. We measured maximum isometric torque ~4 min after the last lengthening contraction in the LSI protocol (D0) and again 3 days later (D3). All control strains lost a similar level of torque. All dysferlin mutant mice except B6.A/J showed a similar reduction in torque immediately after injury; B6.A/J mice showed less susceptibility to initial injury compared to control C57Bl/6J mice as well as other dysferlinopathic strains. DMD^mdx mice showed the highest level of torque loss immediately after injury. At D3, all control strains recovered to near baseline torque levels. All dysferlin mutants except A/J recovered to similar levels as their respective control strains. A/J mice and DMD^mdx mice showed a significant torque deficit at D3. *Significant difference compared to control strain at same time point. ^#Significant difference within same strain between D0 and D3. ^†Significant difference compared to same Dysf mutation at same time point. ^‡Significant difference compared to A/J at same time point.