Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
Figure 6
Quantitation of necrotic fibers. We counted necrotic fibers in H&E-stained cross sections of uninjured and injured TA muscles. Necrotic fibers increased significantly at D3 in all mutant strains. A/J muscle showed the largest increase among the dysferlin mutants, but the extent of necrosis in A/J muscles was significantly less than DMDmdx at this time point. *Significant difference compared to control strain at same time point. #Significant difference within same strain between uninjured and D3. †Significant difference compared to same Dysf mutation at same time point. ‡Significant difference compared to A/J at same time point.
