Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
Figure 9
Regression analyses of contractile torque versus macrophage counts and macrophage counts versus necrosis. A regression analysis of the number of macrophages on D3 as the independent variable and torque at D3 as the dependent variable showed a good linear fit (a). Similarly, analysis of the number of necrotic fibers as the independent variable and the number of macrophages as the dependent variable also showed a good linear fit (b). The analyses suggest that that macrophage counts are a reliable negative predictor of functional recovery at D3 and that the number of necrotic fibers predicts the extent of macrophage invasion.
