Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy

Table 1

Mouse strains. Mouse strains used in the study and number of animals studied per strain.

Strain	Source	JAX mice database stock #	DYSF mutation	N
A/WySnJ	School of Medicine University of Maryland. Breeding pairs from The Jackson Laboratory	000647	N/A. Control strain for A/J mice	8
A/J	School of Medicine University of Maryland. Breeding pairs from The Jackson Laboratory	000646	A retrotransposon insertion within intron 4, causing aberrant splicing of the gene	8
C57Bl/6J	The Jackson Laboratory	000664	N/A. Background strain for B6.A/J	8
B6.A/J	School of Medicine University of Maryland. Breeding pairs from The Jackson Laboratory	012767 B6.A-Dysf^prmd/GeneJ	Progressive muscular dystrophy (prmd) allele from A/J introgressed into the C57BL/6J genetic background	8
SWR/J	The Jackson Laboratory	000689	N/A. Control strain for SJL/J mice	8
SJL/J	The Jackson Laboratory	000686	171 bp in-frame deletion in the encoded mRNA is predicted to remove 57 amino acids from dysferlin	8
C57BL/10J	The Jackson Laboratory	000665	Background strain for B10.SJL	8
B10.SJL	School of Medicine University of Maryland. Breeding pairs from The Jackson Laboratory, and Dr. A. J. Wagers, Harvard University, Cambridge, MA.	011128 B10.SJL-Dysf^im/AwaJ	DYSF mutation (inflammatory myopathy, im) in the SJL strain introgressed into the C57BL/10ScSnHim strain and subsequently bred to C57Bl/10J	8
DMD^mdx	School of Medicine University of Maryland. Breeding pairs from The Jackson Laboratory	001801 C57BL/10ScSn- Dmd^mdx/J	N/A. Dystrophin-deficient mice. C-to-T transition at position 3185, resulting in a termination codon in place of a glutamine codon	8