Table 1: The human ficolins.

M-ficolinL-ficolinH-ficolin

Molecular size (subunit)35 K35 K34 K
Molecular size (native)900 K420 K610 K
LocationNeutrophils, monocytes > serumliver; serumliver; bile; lung; serum
Chemical specificityAcetylated sugarsacetylated compounds;
LPS; 1,3-β-glucans;
lipoteichoic acids;
elastin; steroids
D-fucose > GlcNAc;
polysaccharide from A.viridans
Microbial specificityE. coli; S. aureus;  S. agalactiae S. aureus; S. pneumoniae;
S. typhimurium; E. coli;
P. aeruginosa; M. bovis;
G. lamblia; T. cruzi;
A. fumigatus,
A. viridans; T. cruzi
Complement activationYesYesYes
Opsonic activity?Yes?
Collagenase sensitivityYesYesNo