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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 141395, 13 pages
Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice Hepatic Tissues after Chronic Ethanol Feeding
1Department of Food and Nutrition, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749, Republic of Korea
2Department of Food and Nutrition, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742, Republic of Korea
3Department of Food Science, College of Life Sciences and Biotechnology, Korea University, 1, 5-ga, Anam-dong, Sungbuk-ku, Seoul 136-701, Republic of Korea
Received 13 July 2011; Accepted 8 August 2011
Academic Editor: Masa-Aki Shibata
Copyright © 2012 Areum Cha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Z. Peng, P. A. Borea, K. Varani et al., “Adenosine signaling contributes to ethanol-induced fatty liver in mice,” Journal of Clinical Investigation, vol. 119, no. 3, pp. 582–594, 2009.
- D. W. Crabb, “Recent developments in alcoholism: the liver,” Recent Developments in Alcoholism, vol. 11, pp. 207–230, 1993.
- D. W. Crabb and S. Liangpunsakul, “Alcohol and lipid metabolism,” Journal of Gastroenterology and Hepatology, vol. 21, supplement 3, pp. S56–S60, 2006.
- H. Tsukamoto, H. She, S. Hazra, J. Cheng, and J. Wang, “Fat paradox of steatohepatitis,” Journal of Gastroenterology and Hepatology, vol. 23, supplement 1, pp. S104–S107, 2008.
- M. Fischer, M. You, M. Matsumoto, and D.W. Crabb, “Peroxisome proliferator-activated receptor α (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice,” Journal of Biological Chemistry, vol. 278, no. 30, pp. 7997–8004, 2003.
- O. Gavrilova, M. Haluzik, K. Matsusue et al., “Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass,” Journal of Biological Chemistry, vol. 278, no. 36, pp. 34268–34276, 2003.
- L. E. Nagy, I. Diamond, D. J. Casso, C. Franklin, and A. S. Gordon, “Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter,” Journal of Biological Chemistry, vol. 265, no. 4, pp. 1946–1951, 1990.
- J. G. Puig and I. H. Fox, “Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate,” Journal of Clinical Investigation, vol. 74, no. 3, pp. 936–941, 1984.
- L. E. Nagy, “Ethanol metabolism and inhibition of nucleoside uptake lead to increased extracellular adenosine in hepatocytes,” American Journal of Physiology, vol. 262, no. 5, pp. C1175–C1180, 1992.
- E. S. Chan, M. C. Montesinos, P. Fernandez et al., “Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis,” British Journal of Pharmacology, vol. 148, no. 8, pp. 1144–1155, 2006.
- Z. Peng, P. Fernandez, T. Wilder et al., “Ecto-5′-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis,” FASEB Journal, vol. 22, no. 7, pp. 2263–2272, 2008.
- B. B. Fredholm, “Adenosine, an endogenous distress signal, modulates tissue damage and repair,” Cell Death and Differentiation, vol. 14, no. 7, pp. 1315–1323, 2007.
- R. Guinzberg, I. Laguna, A. Zentella, R. Guzman, and E. Piña, “Effect of adenosine and inosine on ureagenesis in hepatocytes,” Biochemical Journal, vol. 245, no. 2, pp. 371–374, 1987.
- R. Guinzberg, A. Diaz-Cruz, S. Uribe, and E. Pina, “Inhibition of adenosine mediated responses in isolated hepatocytes by depolarizing concentrations of K+,” Biochemical and Biophysical Research Communications, vol. 197, no. 1, pp. 229–234, 1993.
- S. A. Tinton, V. H. Lefebvre, O. C. Cousin, and P. M. Buc-Calderon, “Cytolytic effects and biochemical changes induced by extracellular ATP to isolated hepatocytes,” Biochimica et Biophysica Acta, vol. 1176, no. 1-2, pp. 1–6, 1993.
- E. Gonzalez-Benitez, R. Guinzberg, A. Diaz-Cruz, and E. Pina, “Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP,” European Journal of Pharmacology, vol. 437, no. 3, pp. 105–111, 2002.
- A. K. Dhalla, M. Santikul, M. Smith, M. Y. Wong, J. C. Shryock, and L. Belardinelli, “Antilipolytic activity of a novel partial A1 adenosine receptor agonist devoid of cardiovascular effects: comparison with nicotinic acid,” Journal of Pharmacology and Experimental Therapeutics, vol. 321, no. 1, pp. 327–333, 2007.
- A. K. Dhalla, M. Y. Wong, P. J. Voshol, L. Belardinelli, and G. M. Reaven, “A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents,” American Journal of Physiology, vol. 292, no. 5, pp. E1358–E1363, 2007.
- E. C. Klaasse, A. P. Ijzerman, W. J. de Grip, and M. W. Beukers, “Internalization and desensitization of adenosine receptors,” Purinergic Signalling, vol. 4, no. 1, pp. 21–37, 2008.
- B. S. Bhagwandeen, M. Apte, L. Manwarring, and J. Dickeson, “Endotoxin induced hepatic necrosis in rats on an alcohol diet,” Journal of Pathology, vol. 152, no. 1, pp. 47–53, 1987.
- S. Q. Yang, H. Z. Lin, M. D. Lane, M. Clemens, and A. M. Diehl, “Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 6, pp. 2557–2562, 1997.
- A. M. Diehl, “Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis,” Alcoholism: Clinical and Experimental Research, vol. 25, no. 5, supplement ISBRA, pp. 8S–14S, 2001.
- F. J. Cubero and N. Nieto, “Kupffer cells and alcoholic liver disease,” Revista Espanola de Enfermedades Digestivas, vol. 98, no. 6, pp. 460–472, 2006.
- T. Gustot, A. Lemmers, C. Moreno et al., “Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver,” Hepatology, vol. 43, no. 5, pp. 989–1000, 2006.
- W. L. Guo, L. Gong, Z. F. Ding et al., “Genomic instability in phenotypically normal regenerants of medicinal plant Codonopsis lanceolata benth. et hook. f., as revealed by ISSR and RAPD markers,” Plant Cell Reports, vol. 25, no. 9, pp. 896–906, 2006.
- K. T. Lee, J. Choi, W. T. Jung, J. H. Nam, H. J. Jung, and H. J. Park, “Structure of a new echinocystic acid bisdesmoside isolated from Codonopsis lanceolata roots and the cytotoxic activity of prosapogenins,” Journal of Agricultural and Food Chemistry, vol. 50, no. 15, pp. 4190–4193, 2002.
- K. W. Lee, H. J. Jung, H. J. Park, D. G. Kim, J. Y. Lee, and K. T. Lee, “β-D-xylopyranosyl-()-β-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells,” Biological and Pharmaceutical Bulletin, vol. 28, no. 5, pp. 854–859, 2005.
- Y. G. Lee, J. Y. Kim, J. Y. Lee et al., “Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses,” Journal of Ethnopharmacology, vol. 112, no. 1, pp. 180–188, 2007.
- E. G. Han, H. G. Moon, and S. Y. Cho, “Effect of Codonopsis lanceolata water extract on the levels of lipid in rats fed high fat diet,” Journal of the Korean Society of Food Science and Nutrition, vol. 27, pp. 940–944, 1998.
- C. S. Lieber, L. M. DeCarli, and M. F. Sorrell, “Experimental methods of ethanol administration,” Hepatology, vol. 10, no. 4, pp. 501–510, 1989.
- J. Folch, M. Lees, and G. H. S. Stanley, “A simple method for the isolation and purification of total lipides from animal tissues,” The Journal of Biological Chemistry, vol. 226, no. 1, pp. 497–509, 1957.
- S. Kaviarasan, P. Viswanathan, and C. V. Anuradha, “Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver,” Cell Biology and Toxicology, vol. 23, no. 6, pp. 373–383, 2007.
- R. S. Kumar, M. Ponmozhi, P. Viswanathan, and N. Nalini, “Effect of Cassia auriculata leaf extract on lipids in rats with alcoholic liver injury,” Asia Pacific Journal of Clinical Nutrition, vol. 11, no. 2, pp. 157–163, 2002.
- G. E. Arteel, T. Uesugi, L. N. Bevan et al., “Green tea extract protects against early alcohol-induced liver injury in rats,” Biological Chemistry, vol. 383, no. 3-4, pp. 663–670, 2002.
- E. E. Emeson, M. Vlasios, S. Todd, and T. Majid, “Chronic alcohol feeding inhibits atherogenesis in C57BL/6 hyperlipidemic mice,” American Journal of Pathology, vol. 147, no. 6, pp. 1749–1758, 1995.
- G. Szabo, “Consequences of alcohol consumption on host defence,” Alcohol and Alcoholism, vol. 34, no. 6, pp. 830–841, 1999.
- C. Q. Rogers, J. M. Ajmo, and M. You, “Adiponectin and alcoholic fatty liver disease,” IUBMB Life, vol. 60, no. 12, pp. 790–797, 2008.
- S. Shklyaev, G. Aslanidi, M. Tennant et al., “Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 2, pp. 14217–14222, 2003.
- T. Yamauchi, Y. Nio, T. Maki et al., “Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions,” Nature Medicine, vol. 13, no. 3, pp. 332–339, 2007.
- T. Yamauchi, J. Kamon, Y. Ito et al., “Cloning of adiponectin receptors that mediate antidiabetic metabolic effects,” Nature, vol. 423, no. 6941, pp. 762–769, 2003.
- X. Mao, C. K. Kikani, R. A. Riojas et al., “APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function,” Nature Cell Biology, vol. 8, no. 5, pp. 516–523, 2006.
- M. You, R. V. Considine, T. C. Leone, D. P. Kelly, and D. W. Crabb, “Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice,” Hepatology, vol. 42, no. 3, pp. 568–577, 2005.
- M. A. Jay and J. Ren, “Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus,” Current Diabetes Reviews, vol. 3, no. 1, pp. 33–39, 2007.
- T. Kadowaki, T. Yamauchi, and N. Kubota, “The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS,” FEBS Letters, vol. 582, no. 1, pp. 74–80, 2008.
- T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe, “Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome,” Journal of Clinical Investigation, vol. 116, no. 7, pp. 1784–1792, 2006.
- T. Kadowaki and T. Yamauchi, “Adiponectin and adiponectin receptors,” Endocrine Reviews, vol. 26, no. 3, pp. 439–451, 2005.
- N. Méndez-Sánchez, N. C. Chavez-Tapia, D. Zamora-Valdés, and M. Uribe, “Adiponectin, structure, function and pathophysiological implications in non-alcoholic fatty liver disease,” Mini-Reviews in Medicinal Chemistry, vol. 6, no. 6, pp. 651–656, 2006.
- P. Misra, “AMP activated protein kinase: a next generation target for total metabolic control,” Expert Opinion on Therapeutic Targets, vol. 12, no. 1, pp. 91–100, 2008.
- J. D. Browning and J. D. Horton, “Molecular mediators of hepatic steatosis and liver injury,” Journal of Clinical Investigation, vol. 114, no. 2, pp. 147–152, 2004.
- A. Xu, Y. Wang, H. Keshaw, L. Y. Xu, K. S. Lam, and G. J. Cooper, “The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice,” Journal of Clinical Investigation, vol. 112, no. 1, pp. 91–100, 2003.
- M. You and C. Q. Rogers, “Adiponectin: a key adipokine in alcoholic fatty liver,” Experimental Biology and Medicine, vol. 234, no. 8, pp. 850–859, 2009.
- X. Hou, S. Xu, K. A. Maitland-Toolan et al., “SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase,” Journal of Biological Chemistry, vol. 283, no. 29, pp. 20015–20026, 2008.
- F. Lan, J. M. Cacicedo, N. Ruderman, and Y. Ido, “SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation,” Journal of Biological Chemistry, vol. 283, no. 41, pp. 27628–27635, 2008.
- G. Suchankova, L. E. Nelson, Z. Gerhart-Hines et al., “Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells,” Biochemical and Biophysical Research Communications, vol. 378, no. 4, pp. 836–841, 2009.
- M. Fulco and V. Sartorelli, “Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues,” Cell Cycle, vol. 7, no. 23, pp. 3669–3679, 2008.
- P. Puigserver and B. M. Spiegelman, “Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1 α): transcriptional coactivator and metabolic regulator,” Endocrine Reviews, vol. 24, no. 1, pp. 78–90, 2003.
- R. B. Vega, J. M. Huss, and D. P. Kelly, “The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes,” Molecular and Cellular Biology, vol. 20, no. 5, pp. 1868–1876, 2000.
- R. R. Schumann, S. R. Leong, G. W. Flaggs et al., “Structure and function of lipopolysaccharide binding protein,” Science, vol. 249, no. 4975, pp. 1429–1431, 1990.
- G. L. Su, R. L. Simmons, and S. C. Wang, “Lipopolysaccharide binding protein participation in cellular activation by LPS,” Critical Reviews in Immunology, vol. 15, no. 3-4, pp. 201–214, 1995.
- R. J. Ulevitch and P. S. Tobias, “Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin,” Annual Review of Immunology, vol. 13, pp. 437–457, 1995.
- T. R. Martin, S. M. Mongovin, P. S. Tobias et al., “The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes,” Journal of Leukocyte Biology, vol. 56, no. 1, pp. 1–9, 1994.
- S. D. Wright, R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison, “CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein,” Science, vol. 249, no. 4975, pp. 1431–1433, 1990.
- G. L. Su, R. D. Klein, A. Aminlari et al., “Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and Toll-like receptor 4,” Hepatology, vol. 31, no. 4, pp. 932–936, 2000.
- R. Medzhitov, P. Preston-Hurlburt, E. Kopp et al., “MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways,” Molecular Cell, vol. 2, no. 2, pp. 253–258, 1998.
- K. A. Fitzgerald, E. M. Palsson-Mcdermott, A. G. Bowie et al., “Mal (MyD88-adapter-like) is required for Toll-like recepfor-4 signal transduction,” Nature, vol. 413, no. 6851, pp. 78–83, 2001.
- T. Horng, G. M. Barton, and R. Medzhitov, “TIRAP: an adapter molecule in the Toll signaling pathway,” Nature Immunology, vol. 2, no. 9, pp. 835–841, 2001.
- A. Takaoka, H. Yanai, S. Kondo et al., “Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors,” Nature, vol. 434, no. 2, pp. 243–249, 2005.
- E. Seki, S. de Minicis, C. H. Österreicher et al., “TLR4 enhances TGF-β signaling and hepatic fibrosis,” Nature Medicine, vol. 13, no. 11, pp. 1324–1332, 2007.
- I. Hritz, P. Mandrekar, A. Velayudham et al., “The critical role of Toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88,” Hepatology, vol. 48, no. 4, pp. 1224–1231, 2008.
- J. M. Ajmo, X. Liang, C. Q. Rogers, B. Pennock, and M. You, “Resveratrol alleviates alcoholic fatty liver in mice,” American Journal of Physiology, vol. 295, no. 4, pp. G833–G842, 2008.