Table 1: Plg-Rs on various cell types.

Plg-RsCell typesC-terminal lysineMajor cellular localizationSecretory pathways

(1) Annexin A2Endothelial cells, monocytoid lineageAbsent*Cytosol and or nucleusTranslocation depends on p11 and phosphorylation; activity of L-type like Ca2+ channels and intracellular Ca2+; associates with plasma membrane via phosphatidylserine.
(2) ActinEndothelial cells, carcinoma, catecholaminergic cells, PC-3, HT1080AbsentCytoskeletonNot known
(3) AmphoterinNeuronal cellsAbsentCytoplasmic and extracellularNot known
(4) 𝛼 V 𝛽 3 Endothelial cellsAbsentIntegral membrane proteinClassical endoplasmic reticulum and Golgi pathway
(5) 𝛼 M 𝛽 2 Neutrophils, monocytes, macrophagesAbsentIntegral membrane proteinClassical endoplasmic reticulum and Golgi pathway
(6) 𝛼 IIb 𝛽 3 Platelets, RA synovial fibroblastsAbsentIntegral membrane proteinClassical endoplasmic reticulum and Golgi pathway
(7) Cytokeratin 8Hepatocellular, breast carcinomaPresentCytoskeletonNot known
(8) 𝛼 -EnolaseMonocytes, neutrophils, carcinoma, lymphoid, myoblast neuronsPresentCytosolL-type-like Ca2+ channel and intracellular Ca2+
(9) Histone 2BNeutrophils, monocytoid cells, endothelial cellsPresentNucleusL-type-like Ca2+ channel and intracellular Ca2+. Associates with plasma membrane via phosphatidylserine and heparin sulfate
(10) P11Endothelial cells, HT1080 cellsPresentCytosol and or nucleusL-type-like Ca2+ channel and intracellular Ca2+. Associates with multiple plasma membrane binding partners, including annexin 2
(11) Plg-RKTMonocytes, macrophages, neuronal cellsPresentIntegral membrane proteinClassical endoplasmic reticulum and Golgi pathway
(12) TATA-binding protein-interacting proteinMonocytoid cellsPresentNucleusNot known

*requires cleavage to bind Plg [8].