Commercial Dengue Rapid Diagnostic Tests for Point-of-Care Application: Recent Evaluations and Future Needs?

Table 2

Description of selected recent diagnostic assessments of dengue IgM, IgA, and IgG antibody RDTs.

Assay	Study	Year	Location	Sample timing	Reference comparator	Antibody target	Sensitivity (95% CI)	Specificity (95% CI)
SD Bioline Dengue IgM (1st Generation)	Blacksell et al. [6].	2006	Thailand	Admission	AFRIMS MAC and GAC-ELISA paired samples	IgM	21.8 (17.4–26.7)	98.8 (95.7–99.9)
	Nga et al. [32]	2007	Vietnam	3 weeks illness	Focus IgM/IgG ELISA	IgM	10.6 (6.0–18.0)	99.0 (94.3–99.8)
						IgG	90.4 (84.6–94.2)	88.9 (77.8–94.8)
SD Bioline Dengue Duo (2nd Generation)	Wang and Sekaran [21]	2010	Malaysia	1–15 days	Virus isolation, RT-PCR, rising titer in a paired samples using MAC ELISA	IgM	53.5	100
	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2–7 days illness	AFRIMS MAC and GAC-ELISA paired samples	IgM	79.2 (70.5–87.2)	89.4 (83.5–93.7)
Panbio Dengue Duo cassette	Blacksell et al. [6]	2006	Thailand	Admission	AFRIMS MAC and GAC-ELISA paired samples	IgM	65.3 (59.9–70.5)	97.6 (93.9–99.3)
	Nga et al. [32]	2007	Vietnam	3 weeks illness	Focus IgM/IgG ELISA	IgM	67.3 (57.8–75.6)	91.7 (84.4–95.7)
						IgG	66.4 (58.4–73.6)	94.4 (84.9–98.1)
	Moorthy et al. [33]	2009	South India	Not stated	Panbio MAC and GAC-ELISA	IgM	81.8	75.0
						IgG	87.5	66.6
	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2–7 days illness	AFRIMS MAC and GAC-ELISA paired samples	IgM	70.7 (60.7–79.4)	80.0 (73.0–85.9)
Merlin IgM	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2–7 days illness	AFRIMS MAC and GAC-ELISA paired samples	IgM	72.7 (62.9–81.2)	73.8 (66.2–80.4)
Biosynex IgM	Blacksell et al. [19]	2011	Sri Lanka	Median 5; IQR 2–7 days illness	AFRIMS MAC and GAC-ELISA paired samples	IgM	79.8 (70.5–87.2)	46.3 (38.3–54.3)
MP Diagnostics ASSURE	Tan et al. [34]	2011	Singapore	Acute	NS1 Ag and MAC ELISAs	IgA	86.7	86.1
	Ahmed et al. [35]	2010	Bangladesh	Acute and Convalescent	NS1 Ag and MAC ELISAs	IgA	99.4	100