Table 2: Description of selected recent diagnostic assessments of dengue IgM, IgA, and IgG antibody RDTs.

AssayStudyYearLocationSample timingReference comparatorAntibody targetSensitivity (95% CI)Specificity (95% CI)

SD Bioline Dengue IgM (1st Generation)Blacksell et al. [6].2006ThailandAdmissionAFRIMS MAC and GAC-ELISA paired samplesIgM21.8 (17.4–26.7)98.8 (95.7–99.9)
Nga et al. [32]2007Vietnam3 weeks illnessFocus IgM/IgG ELISAIgM10.6 (6.0–18.0)99.0 (94.3–99.8)
IgG90.4 (84.6–94.2)88.9 (77.8–94.8)

SD Bioline Dengue Duo (2nd Generation)Wang and Sekaran [21]2010Malaysia1–15 daysVirus isolation, RT-PCR, rising titer in a paired samples using MAC ELISAIgM53.5100
Blacksell et al. [19]2011Sri LankaMedian 5; IQR 2–7 days illnessAFRIMS MAC and GAC-ELISA paired samplesIgM79.2 (70.5–87.2)89.4 (83.5–93.7)

Panbio Dengue Duo cassetteBlacksell et al. [6]2006ThailandAdmissionAFRIMS MAC and GAC-ELISA paired samplesIgM65.3 (59.9–70.5)97.6 (93.9–99.3)
Nga et al. [32]2007Vietnam3 weeks illnessFocus IgM/IgG ELISAIgM67.3 (57.8–75.6)91.7 (84.4–95.7)
IgG66.4 (58.4–73.6)94.4 (84.9–98.1)
Moorthy et al. [33]2009South IndiaNot statedPanbio MAC and GAC-ELISAIgM81.875.0
IgG87.566.6
Blacksell et al. [19]2011Sri LankaMedian 5; IQR 2–7 days illness AFRIMS MAC and GAC-ELISA paired samplesIgM70.7 (60.7–79.4)80.0 (73.0–85.9)

Merlin IgMBlacksell et al. [19]2011Sri LankaMedian 5; IQR 2–7 days illnessAFRIMS MAC and GAC-ELISA paired samplesIgM72.7 (62.9–81.2)73.8 (66.2–80.4)

Biosynex IgMBlacksell et al. [19]2011Sri LankaMedian 5; IQR 2–7 days illnessAFRIMS MAC and GAC-ELISA paired samplesIgM79.8 (70.5–87.2)46.3 (38.3–54.3)

MP Diagnostics ASSURETan et al. [34]2011SingaporeAcuteNS1 Ag and MAC ELISAsIgA86.786.1
Ahmed et al. [35]2010BangladeshAcute and ConvalescentNS1 Ag and MAC ELISAsIgA99.4100