|
| Assay | Study | Year | Location | Sample timing | Reference comparator | Sensitivity (95% CI) | Specificity (95% CI) |
|
| Dussart et al. [44] | 2008 | French Guiana | 82% <5 days illness | RT-PCR or paired MAC and GAC-ELISA | 77.6 (72.1–82.4) | 100 (92.6–100) |
| Shu et al. [42] | 2009 | Taiwan | Median 2; 1–7 days illness | RT-PCR or paired MAC and GAC-ELISA | 77.3 (0.54–0.92) | 100 |
| Hang et al.[41] | 2009 | Vietnam | 1–6 days illness | RT-PCR or paired MAC and GAC-ELISA | 72.8 (64.1–80.3) | 100 (91.6–100) |
| Chaiyaratana et al. [43] | 2009 | Thailand | 1–8 days illness | NS1 Ag ELISA | 98.9 (96.8–100) | 90.6 (85.6–95.7) |
| Zainah et al. [45] | 2009 | Malaysia | Not stated | Viral culture, nested RT-PCR, NS1 Ag ELISA | 90.4 (86.6–94.4) | 99.5 (97.4–99.9) |
| Biorad STRIP | Ramierez et al. [46] | 2009 | Venezuela | 2–6 days illness | RT-PCR or paired MAC-ELISA | 67.8 (57.4–76.7) | 94.4 (80.9–99.4) |
| Lima et al. [47] | 2009 | Brazil | 1–6 days illness | Combinations of viral culture, nested RT-PCR, NS1 Ag ELISA | 89.6 (84.7–93.2) | 99.1 (96.9–99.9) |
| Pok et al. [38] | 2010 | Singapore | 1-8 days illness | “Recife” classification (7) | 78.9 (70–86.1) | 99 (94.6–99.9) |
| Tricou et al. [39] | 2010 | Vietnam | 1–6 days illness | RT-PCR or paired MAC and GAC-ELISA | 61.6 (55.2–67.8) | 100 (93.8–100) |
| Najioullah et al. [37] | 2011 | Martinique | Not stated | RT-PCR | 49.4% (43.2–55.6) | 100 |
| Osorio et al. [40] | 2010 | Colombia | Median 4; range 2–7 days illness | Viral culture, nested RT-PCR or paired MAC and GAC-ELISA | 57.7 (47.6–67.3) | 95.3 (84.2–99.4) |
| Blacksell et al. [19] | 2011 | Sri Lanka | Median 5; IQR 2–7 days illness | AFRIMS MAC and GAC-ELISA paired samples | 58.6 (48.2–68.4) | 98.8 (95.6 −99.9) |
|
| Tricou et al. [39] | 2010 | Vietnam | 1–6 days illness | RT-PCR or paired MAC and GAC-ELISA | 62.4 (56.1–68.5) | 100 (93.8–100) |
| SD Bioline Dengue Duo | Wang and Sekaran [21] | 2010 | Malaysia | 1–15 days | Virus isolation, RT-PCR, paired MAC ELISA | 65.4 (58.5–72.3) | 98.8 (96.2–100) |
| Osorio et al. [40] | 2010 | Colombia | Median 4; range 2–7 days illness | Viral culture, nested RT-PCR or paired MAC and GAC-ELISA | 51 (44.1–57.7) | 96.7 (90.8–99.3) |
| Blacksell et al. [19] | 2011 | Sri Lanka | Median 5; IQR 2–7 days illness | AFRIMS MAC and GAC-ELISA paired samples | 48.5 (38.5–58.7) | 99.4 (96.6–100) |
|
| Panbio Early Rapid NS1 | Fry et al. [20] | 2011 | Vietnam | 1-5 days; 84.5%<3 days illness | RT-PCR or paired MAC and GAC-ELISA | 69.2 (62.8–75.6) | 96% (92.2– 99.8) |
| Fry et al. [20] | 2011 | Malaysia | 1-15 days; 70% ≤5 days illness | RT-PCR or paired MAC and GAC-ELISA | 68.9 (61.8–76.1) | 96.7 (82.8– 99.9) |
| Blacksell et al. [19] | 2011 | Sri Lanka | Median 5; IQR 2–7 days illness | AFRIMS MAC and GAC-ELISA paired samples | 58.6 (48.2–68.4) | 92.5 (87.3–96.1) |
|
