Table 4: Description of selected recent diagnostic assessments of dengue RDT combining NS1 antigen, IgM, and IgG antibody results.

AssayStudyYearLocationSample timingReference comparatorAnalyte combinationSensitivity (95% CI)Specificity (95% CI)

Tricou et al. [39]2010Vietnam1–6 days illnessRT-PCR or paired MAC and GAC-ELISANS1/IgM75.5 (69.6 – 80.8)100 (93.8 – 100)
NS1/IgM/IgG83.7 (78.4 – 88.1)97.9 (88.7 – 99.9)
Wang and Sekaran [21]2010Malaysia1–15 daysVirus isolation, RT-PCR, rising titer in a paired samples using MAC ELISANS1/IgM88.7 (84.0 –93.3)98.8 (96.3–100)
SD Dengue Duo BiolineOsorio et al. [40]2010ColombiaMedian 4; range 2–7 days illnessViral culture, nested RT-PCR or paired MAC and GAC-ELISANS1/IgM78.4 (72.4 –83.7)91.3 (83.6–96.2)
NS1/IgM/IgG80.7 (75–85.7)89.1 (81–94.7)
Blacksell et al. [19]2011Sri LankaMedian 5; IQR 2-7 days illnessAFRIMS MAC and GAC-ELISA paired samplesNS1/IgM92.9 (83.9 –97.1)88.8 (82.8–93.2

Panbio Early Rapid NS1 and Duo assayFry et al. [20]2011Malaysia1–15 days; 70% ≤5 days illnessRT-PCR or paired MAC and GAC-ELISANS1/IgM89.0 (85.2 – 92.8)Not reported
NS1/IgM/IgG93.0Not reported
Blacksell et al. [19]2011Sri LankaMedian 5; IQR 2–7 days illnessAFRIMS MAC and GAC-ELISA paired samplesNS1/IgM89.9 (82.2–95.0)75.0 (67.6–81.5)