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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 165296, 7 pages
http://dx.doi.org/10.1155/2012/165296
Research Article

Transfer of Bone-Marrow-Derived Mesenchymal Stem Cells Influences Vascular Remodeling and Calcification after Balloon Injury in Hyperlipidemic Rats

1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2Department of Cardiology, The Third Affiliated Hospital, Inner Mongolia Medical College, BaoTou, Inner Mongolia 014010, China

Received 19 December 2011; Revised 27 February 2012; Accepted 29 February 2012

Academic Editor: Monica Fedele

Copyright © 2012 Jianquan Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bone-marrow-derived mesenchymal stem cells (BM-MSCs) were found to markedly increase atherosclerotic lesion size. The aim of this paper was to investigate whether BM-MSCs contribute to vascular remodeling and calcification after balloon injury in hyperlipidemic rats. Labeled BM-MSCs were found in the lesion of hyperlipidemic rats after balloon injury. Comparing injury group, transferred BM-MSCs significantly triggered vascular negative remodeling, characterized by the changes of remodeling index ( 0 . 6 2 8 ± 0 . 0 2 9 3 versus 0 . 5 4 4 ± 0 . 0 2 1 7 ), neointimal area ( 0 . 0 7 8 ± 0 . 0 1 5  mm2 versus 0 . 0 9 8 ± 0 . 0 1 9  mm2), PCNA index ( 2 3 . 9 1 ± 6 . 5 9 % versus 4 3 . 1 1 ± 5 . 3 1 %), and percentage of stenosis ( 1 8 . 2 0 ± 1 . 0 9 % versus 3 0 . 5 8 ± 1 . 2 1 %). Apparent vascular calcification was detected in medial layers at 6 weeks after balloon angioplasty, which may be associated with upregulation of bone morphogenetic protein-2 (BMP-2). Our data indicated that unselected BM-MSCs transfer may induce vascular remodeling and calcification after balloon injury in hyperlipidemic rats.