Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility

<table>Relationship between logarithm of local anesthetic concentration producing 50% of the local anesthetic-induced maximal contraction (ED<sub>50</sub>) in isolated endothelium-denuded aorta and logarithm of octanol/buffer partition coefficient (log <svg height="10.325" id="M33" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
</text>
</g>
</g>
</svg>) of local anesthetics. All values are shown as mean ± SD. Each anesthetic was tested in aortic rings from six rats.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility 