Table 2: The concentration ( E D 5 0 ) eliciting 50% of maximum contraction induced by local anesthetics in endothelium-denuded aorta.

Local anestheticsNLog E D 5 0 Contraction induced by 60 mM KCl (g)

Levobupivacaine6−4.65 ± 0.082.94 ± 0.66
Ropivacaine6−4.11 ± 0.07*3.24 ± 0.51
Lidocaine6−3.74 ± 0.15*,†2.88 ± 0.49
Mepivacaine6−3.20 ± 0.07*,†,‡2.91 ± 0.36

Values are expressed as mean ± SD.
N: number of rats.
*P < 0.001 versus levobupivacaine, P < 0.001 versus ropivacaine, P < 0.001 versus lidocaine.