Table 3: Ridge regression analysis using standardized regression coefficients regarding the relationship between the dependent variable (representing the local anesthetic concentration eliciting 50% of maximum contraction) and the independent variables (representing physicochemical properties).

Independent variablesStandardized regression coefficient

Octanol/buffer partition coefficient (log [octanol/buffer partition coefficient]) −0.4701
Molecular weight (g/mol) (base form)+0.0169
pKa (−log Ka)−0.2068
Potency−0.2428

Ka: dissociation constant.