About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 172420, 11 pages
http://dx.doi.org/10.1155/2012/172420
Research Article

Rapamycin Conditioning of Dendritic Cells Differentiated from Human ES Cells Promotes a Tolerogenic Phenotype

1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
2Translational Research and Immunology, Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA

Received 14 July 2011; Accepted 7 October 2011

Academic Editor: Ken-ichi Isobe

Copyright © 2012 Kathryn M. Silk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Klimanskaya, N. Rosenthal, and R. Lanza, “Derive and conquer: sourcing and differentiating stem cells for therapeutic applications,” Nature Reviews Drug Discovery, vol. 7, no. 2, pp. 131–142, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. P. J. Fairchild, N. J. Robertson, S. L. Minger, and H. Waldmann, “Embryonic stem cells: protecting pluripotency from alloreactivity,” Current Opinion in Immunology, vol. 19, no. 5, pp. 596–602, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Steinman and J. Banchereau, “Taking dendritic cells into medicine,” Nature, vol. 449, no. 7161, pp. 419–426, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Hawiger, K. Inaba, Y. Dorsett et al., “Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo,” Journal of Experimental Medicine, vol. 194, no. 6, pp. 769–779, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. S. F. Yates, A. M. Paterson, K. F. Nolan et al., “Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation,” Journal of Immunology, vol. 179, no. 2, pp. 967–976, 2007. View at Scopus
  6. M. V. Dhodapkar, R. M. Steinman, J. Krasovsky, C. Munz, and N. Bhardwaj, “Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells,” Journal of Experimental Medicine, vol. 193, no. 2, pp. 233–238, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. P. J. Fairchild, S. Cartland, K. F. Nolan, and H. Waldmann, “Embryonic stem cells and the challenge of transplantation tolerance,” Trends in Immunology, vol. 25, no. 9, pp. 465–470, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Senju, H. Suemori, H. Zembutsu et al., “Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function,” Stem Cells, vol. 25, no. 11, pp. 2720–2729, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Hirata, S. Senju, H. Matsuyoshi, D. Fukuma, Y. Uemura, and Y. Nishimura, “Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand 1,” Journal of Immunology, vol. 174, no. 4, pp. 1888–1897, 2005. View at Scopus
  10. A. J. Leishman, K. M. Silk, and P. J. Fairchild, “Pharmacological manipulation of dendritic cells in the pursuit of transplantation tolerance,” Current Opinion in Organ Transplantation, vol. 16, no. 4, pp. 372–378, 2011. View at Publisher · View at Google Scholar
  11. H. R. Turnquist, G. Raimondi, A. F. Zahorchak, R. T. Fischer, Z. Wang, and A. W. Thomson, “Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance,” Journal of Immunology, vol. 178, no. 11, pp. 7018–7031, 2007. View at Scopus
  12. V. Sordi, G. Bianchi, C. Buracchi et al., “Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin,” Transplantation, vol. 82, no. 6, pp. 826–834, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Reichardt, C. Dürr, D. Von Elverfeldt et al., “Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation,” Journal of Immunology, vol. 181, no. 7, pp. 4770–4779, 2008. View at Scopus
  14. J. M. Sacks, Y. R. Kuo, A. Taieb et al., “Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression,” Plastic and Reconstructive Surgery, vol. 121, no. 1, pp. 37–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Ikeguchi, J. M. Sacks, J. V. Unadkat et al., “Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression,” Transplantation, vol. 85, no. 2, pp. 237–246, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Taner, H. Hackstein, Z. Wang, A. E. Morelli, and A. W. Thomson, “Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival,” American Journal of Transplantation, vol. 5, no. 2, pp. 228–236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. E. K. Horibe, J. Sacks, J. Unadkat et al., “Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion,” Transplant Immunology, vol. 18, no. 4, pp. 307–318, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Haidinger, M. Poglitsch, R. Geyeregger et al., “A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation,” Journal of Immunology, vol. 185, no. 7, pp. 3919–3931, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Y. Tseng, K. P. Nishimoto, K. M. Silk et al., “Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells,” Regenerative Medicine, vol. 4, no. 4, pp. 513–526, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Xu, M. S. Inokuma, J. Denham et al., “Feeder-free growth of undifferentiated human embryonic stem cells,” Nature Biotechnology, vol. 19, no. 10, pp. 971–974, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Li, S. Powell, E. Brunette, J. Lebkowski, and R. Mandalam, “Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products,” Biotechnology and Bioengineering, vol. 91, no. 6, pp. 688–698, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. Woltman, J. W. De Fijter, S. W. A. Kamerling et al., “Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages,” Blood, vol. 98, no. 1, pp. 174–180, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Wang, K. Pino-Lagos, V. C. De Vries, I. Guleria, M. H. Sayegh, and R. J. Noelle, “Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 27, pp. 9331–9336, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Seddiki, B. Santner-Nanan, J. Martinson et al., “Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells,” Journal of Experimental Medicine, vol. 203, no. 7, pp. 1693–1700, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Liu, A. L. Putnam, Z. Xu-yu et al., “CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells,” Journal of Experimental Medicine, vol. 203, no. 7, pp. 1701–1711, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Hochweller and S. M. Anderton, “Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration,” European Journal of Immunology, vol. 34, no. 4, pp. 990–998, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. C. P. Larsen, E. T. Elwood, D. Z. Alexander et al., “Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways,” Nature, vol. 381, no. 6581, pp. 434–438, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Honey, S. P. Cobbold, and H. Waldmann, “CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression,” Journal of Immunology, vol. 163, no. 9, pp. 4805–4810, 1999. View at Scopus
  29. L. Graca, K. Honey, E. Adams, S. P. Cobbold, and H. Waldmann, “Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance,” Journal of Immunology, vol. 165, no. 9, pp. 4783–4786, 2000. View at Scopus
  30. S. Martin, R. Agarwal, G. Murugaiyan, and B. Saha, “CD40 expression levels modulate regulatory T cells in Leishmania donovani infection,” Journal of Immunology, vol. 185, no. 1, pp. 551–559, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. D. Muller, G. Mai, P. Morel et al., “Anti-CD154 mAB and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation,” PLoS One, vol. 5, no. 4, Article ID e10352, 2010. View at Publisher · View at Google Scholar · View at Scopus