Mechanism of Growth Inhibition of Prostate Cancer Xenografts by Valproic Acid

Table 1

Immunohistochemistry staining scores of various markers in xenografts of control and treatment arm.

	LnCaP					C4-2					DU145
	Weighted IHC score					Weighted IHC score					Weighted IHC score
	No Tx	0.4% VPA	Fold change		P value	No Tx	0.4% VPA	Fold change		P value	No Tx	0.4% VPA	Fold change		P value
H3Ac	144.7	175.8	▲	1.22	0.038	164.8	199.2	▲	1.21	0.032	189.8	212.6	▲	1.12	0.016
p21	2.0	7.0	▲	3.50	0.046	52.6	91.9	▲	1.75	0.033	40.9	62.6	▲	1.53	0.029
Cyclin D1	120.2	102.8	▼	0.85	0.030	160.0	128.8	▼	0.80	0.001	149.4	111.3	▼	0.74	0.006
p27	0.6	5.3	▲	4.08	0.035	20.1	27.1	∆	1.35	0.658	67.2	91.3	▲	1.36	0.012
CK18	1.3	2.8	∆	2.22	0.314	15.4	45.1	▲	2.92	0.030	113.3	180.0	▲	1.59	0.042
AR	159.0	132.3	▼	0.83	0.050	147.2	145.4	◁▷	0.99	0.860	0.0	0.0
Ki67	130.7	144.4	◁▷	1.11	0.405	124.4	135.0	◁▷	1.08	0.248	118.3	80.7	▼	0.68	0.042
TUNEL	91.9	111.9	▲	1.22	0.039	87.2	129.2	▲	1.48	0.007	179.4	195.6	◁▷	1.09	0.145
	# microvessel/mm^2					# microvessel/mm^2					# microvessel/mm^2
MVD (CD34)	57.56	38.84	▼	0.67	0.008	57.08	23.45	▼	0.41	0.010	31.28	25.25	▽	0.81	0.142

▲: significant increase, ∆: nonsignificant increase, ▼: significant decrease, ▽: non significant decrease, ◁▷: no change.