Table 2: Immunohistochemistry staining scores of various markers in tissue microarrays created from cell lines treated with 0, 0.6, and 1.2 mM of valproic acid for 14 days.


LnCaP (in vitro)
Weighted IHC scoreFold changeP value
VPA0 mM0.6 mM1.2 mM0.6 mM1.2 mM0 versus 0.60 versus 1.20.6 versus 1.2

p2150651101.302.20<0.001<0.001<0.001
p27713171.862.43<0.001<0.001<0.001
CK1836531151.473.19<0.001<0.001<0.001
AR1641501170.910.71<0.001<0.001<0.001
Ki672301751350.760.59<0.001<0.001<0.001

C4-2 (in vitro)
Weighted IHC scoreFold changeP value
VPA0 mM0.6 mM1.2 mM0.6 mM1.2 mM0 versus 0.60 versus 1.20.6 versus 1.2

p21851001401.181.65<0.001<0.001<0.001
p274258731.381.74<0.001<0.001<0.001
CK1865801051.231.62<0.001<0.001<0.001
AR2202001850.910.84<0.001<0.001<0.001
Ki672001801000.900.50<0.001<0.001<0.001

▲: significant increase,∆: nonsignificant increase, ▼: significant decrease, ▽: non significant decrease, ◁▷: no change.