Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese

Table 3

Allele frequencies and genotype distributions of rs873458 and rs2878677 in MFN2 gene among stage 1 and stage 2 populations.

	SNP	Genotype					Allele
			T2D (%)	control (%)	𝑃/𝑃𝑐	OR (95%CI)		T2D (%)	control (%)	𝑃	OR (95% CI)
Stage 1	rs873458		555	638
		A/A	50 (9.0)	105 (16.5)	0.0007/0.01	0.80 (0.67–0.95)	A	382 (34.4)	510 (40.0)	0.005	0.79 (0.67–0.93)
		A/G	282 (50.8)	300 (47.0)			G	728 (65.6)	766 (60.0)
		G/G	223 (40.2)	233 (36.5)
	rs2878677		549	643
		T/T	124 (22.6)	108 (16.8)	0.03/0.02	0.83 (0.71–0.97)	T	487 (44.4)	503 (39.1)	0.01	0.81 (0.68–0.95)
		C/T	239 (43.5)	287 (44.6)			C	611 (55.6)	783 (60.9)
		C/C	186 (33.9)	248 (38.6)
Stage 2	rs873458		539	412
		A/A	72 (13.4)	58 (14.1)	0.21/0.08	0.84 (0.69–1.02)	A	386 (35.8)	321 (39.0)	0.16	0.87 (0.72–1.05)
		A/G	242 (44.9)	205 (49.8)			G	692 (64.2)	503 (61.0)
		G/G	225 (41.7)	149 (36.2)
	rs2878677		545	417
		T/T	135 (24.8)	78 (18.7)	0.05/0.02	0.80 (0.67–0.97)	T	516 (47.8)	348 (41.8)	0.01	0.79 (0.65–0.94)
		C/T	248 (45.5)	192 (46.0)			C	564 (52.2)	484 (58.2)
		C/C	162 (29.7)	147 (35.3)
Combinded	rs873458		1094	1050
		A/A	122 (11.2)	163 (15.5)	0.005/0.002	0.82 (0.72–0.93 )	A	768 (35.1)	831 (39.6)	0.002	0.83 (0.73–0.93)
		A/G	524 (47.9)	505 (48.1)			G	1420 (64.9)	1269 (60.4)
		G/G	448 (41.0)	382 (36.4)
	rs2878677		1089	1059
		T/T	259 (23.8)	186 (17.6)	0.0006/0.0004	0.81 (0.72–0.91)	T	1003 (46.1)	851 (40.2)	0.0001	0.79 (0.69–0.89)
		C/T	485 (44.5)	479 (45.2)			C	1183 (53.9)	1267 (59.8)
		C/C	345 (31.7)	394 (37.2)

𝑃 had no adjustment, whereas Pc were adjusted for age, sex, and BMI.