Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese

Table 5

Models of multi-loci interaction on the risk of T2D by MDR.

Gene-gene	Combination of multiloci	^*𝑃 value	CV consistency	Testing accuracy (%)
MFN2-ESRRA	rs873458/rs3766742	0.0007	7/10	56.1
	rs873458/rs2878677/rs3766741	<0.0001	4/10	56.2
	rs2878677/rs3766741/rs731703/rs11600990	<0.0001	3/10	57.7
MFN2-PGC-1α	rs7656250/rs13131226	0.0002	7/10	56.4
	rs2878677/rs3774923/rs7656250	<0.0001	10/10	59.9
	rs2878677/rs3774923/rs7656250/rs13131226	<0.0001	9/10	63.9

Rs873458, rs2878677, rs3766742, rs3766741 located in MFN2, rs731703 and rs11600990 located in ESRRA，rs7656250, rs13131226, and rs3774923 located in PGC -1α. 𝑃 value based on 1,000 permutations.