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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 206918, 8 pages
http://dx.doi.org/10.1155/2012/206918
Review Article

Overview of Plant-Made Vaccine Antigens against Malaria

Laboratorio de Biotecnología Vegetal, Instituto Investigaciones Biotecnológicas-Instituto Tecnológico Chascomús, Camino de Circunvalación km 8.2, 7130 Buenos Aires, Argentina

Received 17 March 2012; Revised 22 May 2012; Accepted 23 May 2012

Academic Editor: Diego Gomez-Casati

Copyright © 2012 Marina Clemente and Mariana G. Corigliano. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper is an overview of vaccine antigens against malaria produced in plants. Plant-based expression systems represent an interesting production platform due to their reduced manufacturing costs and high scalability. At present, different Plasmodium antigens and expression strategies have been optimized in plants. Furthermore, malaria antigens are one of the few examples of eukaryotic proteins with vaccine value expressed in plants, making plant-derived malaria antigens an interesting model to analyze. Up to now, malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice. Therefore, plant production platforms offer wonderful prospects for improving the access to malaria vaccines.