Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and Metastasis

Figure 1

StVOrth-2 and StVOrth-3 peptides. StVOrth-2 (highlighted in blue) consists of residues 78–102 of the parent PEDF sequence. StVOrth-3 (highlighted in red) consists of residues 90–114. StVOrth-2 and StVOrth-3 have previously been shown to inhibit osteosarcoma cell proliferation and promote osteosarcoma cell adhesion to collagen I in vitro, respectively [7]. *ERT and 44-mer peptide sequences, as described by Filleur et al. [6], overlap with the StVOrth-2 and StVOrth-3 sequences.