Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and Metastasis

Figure 5

Systemically delivered StVOrth-3 inhibits progression of pulmonary metastatic disease. (a) Haematoxylin- and eosin-stained sections of lung tissue show micrometastases (arrows) disrupting the native alveolar architecture. Metastatic lesions were predominately subpleural and around larger airways. (b) Number of pulmonary micrometastases per lung section at 20x magnification (±SEM). (c) Cross-sectional areas of pulmonary micrometastases (±SEM). *𝑃<0.05, one-way ANOVA.

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