248764.fig.003
Figure 3: Schematic representation of possible mechanisms and cellular targets involved in the neurotoxicity MeHg-induced: (1) glutamate dyshomeostasis and Ca2+ intracellular dysregulation; (2) mitochondrial dysfunction; (3) cytoskeletal disruption; (4) DNA damage; (5) SER dysfunction; (6) thiol depletion (especially glutathione). This scheme is merely representative and the scale of structures does not represent the real size.