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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 259693, 9 pages
http://dx.doi.org/10.1155/2012/259693
Research Article

All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation

1Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Anhui 230022, China
2Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Anhui 230601, China
3Laboratory of Molecular Biology, Anhui Medical University, Anhui 230032, China

Received 2 November 2011; Revised 21 December 2011; Accepted 21 December 2011

Academic Editor: Saulius Butenas

Copyright © 2012 Birong Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. All-trans-retinoic acid (atRA) is effective for many proliferative diseases. We investigated the protective effects of atRA against atherosclerosis. Methods. Rabbits were randomly allocated to receive basal diet or an HFD for 4 weeks. HFD group then received rosuvastatin (3 mg/day), atRA (5 mg/kg/day), or the same volume of vehicle, respectively, for next 8 weeks. Results. HFD group showed increases in plasma lipids and aortic plaque formation. P-selectin expression and fibrinogen binding on platelets or deposition on the intima of the aorta also increased significantly as did the levels of TNF-α, IL-6, and fibrinogen in plasma. After 8 weeks of treatment with atRA, there was a significant decrease in plasma lipids and improvement in aortic lesions. AtRA also inhibited the expression of P-selectin and fibrinogen binding on platelets and deposition on the intima of the aorta. Conclusion. AtRA can ameliorate HFD-induced AS in rabbits by inhibiting platelet activation and inflammation.