260983.fig.001a
(a)
260983.fig.001b
(b)
260983.fig.001c
(c)
260983.fig.001d
(d)
Figure 1: CD73−/− mice develop more severe clinical signs of IBD than WT mice. (a) WT (circles) and CD73−/− (squares) mice were given 3% DSS in drinking water and weighed daily for 10 days. Results are represented as % of initial weight (±SEM, summary of 5 experiments, 𝑛 = 2 6 , * 𝑃 < 0 . 0 5 , ** 𝑃 < 0 . 0 1 , *** 𝑃 < 0 . 0 0 5 ). (b) Mean (±SEM, 𝑛 = 4 , * 𝑃 < 0 . 0 5 , representative of 5 experiments) colonic blood score is displayed (0 = no blood in colon; 1 = blood in 25% of colon; 2 = blood in 50% of colon; 3 = blood in 75% of colon; 4 = blood in 100% of colon). (c) Mean (±SEM, 𝑛 = 4 , * 𝑃 < 0 . 0 5 , representative of 5 experiments) colon length (cm) is displayed, along with (d) a representative photograph.