Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNF
Figure 4
Effect of the four analogs on the protein expressions of TLR2, TNFα, and caspase3 in PC12 cells with oxygen-glucose deprivation (OGD). The protein level was measured by Western blot. Model means treatment with oxygen-glucose deprivation. 0.5, 1, 3, and 6 h mean the time of reperfusion process after OGD. (a) stands for baicalin effect; (b) stands for wogonoside effect; (c) stands for baicalein effect; (d) stands for wogonin effect. Baicalin, wogonoside, and wogonin were used in a concentrating of 10 μg/mL, and the baicalein was used in a concentrating of 1 μg/mL. * versus normal control. # versus model group. Data were presented as mean ± SD from three independent experiments.
