Pharmacokinetic Models for FcRn-Mediated IgG Disposition

Figure 3

Simulated PK profiles using the rat cutoff model. All rats receive 8 mg/kg 7E3, as well as IVIG at indicated dose levels. Plasma and peripheral concentrations of 7E3, IVIG IgG, and endogenous IgG are plotted.

(a)

(b)

(c)

(d)

(e)

(f)