Review Article
Pharmacokinetic Models for FcRn-Mediated IgG Disposition
Table 1
Summary of the cutoff PK model parameter estimates in rats and mice based on the PK data simulated by using Hansenโs PK models.
| | Parameter | Rat | Mouse | | Estimate | %RSE | Estimate | %RSE |
| | (mL/kg) | 39.8 | 0.563% | 66.8 | 1.46% | | Max (ฮผM) | 108 | 0.0756% | 20.1 | 0.557% | | (mL/d/kg) | 81.0 | 0.519% | 72.1 | 3.47% | | (mL/d/kg) | 2580 | 6.7% | 564 | 29.8% | | (mL/kg) | 29.3 | 0.594% | 65.5 | 7.43% | | (mL/d/kg) | 24.5 | 0.420% | 5.63 | 12.5% | | (ฮผM) | 103 (fixed) | โ | 14.7 (fixed) | โ | | EPS | 0.000302 | 43.7% | 0.00289 | 68.5% |
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In the mouse model, the MAX estimate is for FcRn WT mice; MAX is 0 in FcRn KO mice.
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