Research Article

In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall

Figure 5

The disappearance of injected AGP from the plasma of mice following intravenous injection is altered by systemic hyaluronidase treatment. Radioiodinated AGP was injected into mice with (AGP + hy’ase) or without (AGP) concurrent hyaluronidase treatment, and acid-precipitable radioactivity, shown as the percentage of the dose remaining in plasma, was followed over time, 𝑛 = 6 ± S D .
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