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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 298657, 20 pages
http://dx.doi.org/10.1155/2012/298657
Review Article

The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models

1Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade de Sao Paulo, 14040-900 Ribeirão Preto, SP, Brazil
2Institut d'lnvestigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, 08036 Barcelona, Spain

Received 1 December 2011; Accepted 23 February 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 M. Mendes-Braz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present review focuses on the numerous experimental models used to study the complexity of hepatic ischemia/reperfusion (I/R) injury. Although experimental models of hepatic I/R injury represent a compromise between the clinical reality and experimental simplification, the clinical transfer of experimental results is problematic because of anatomical and physiological differences and the inevitable simplification of experimental work. In this review, the strengths and limitations of the various models of hepatic I/R are discussed. Several strategies to protect the liver from I/R injury have been developed in animal models and, some of these, might find their way into clinical practice. We also attempt to highlight the fact that the mechanisms responsible for hepatic I/R injury depend on the experimental model used, and therefore the therapeutic strategies also differ according to the model used. Thus, the choice of model must therefore be adapted to the clinical question being answered.