The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models

Table 2

Additives to UW solution to protect liver against ischemia/reperfusion. Nitric oxide, NO; platelet-activating factor, PAF; sinusoidal endothelial cells, SEC.

Additives to UW solution
Liver transplantation
Drug	Specie	Ischemic time	Effect
Ruthenium red (mitochondrial Ca^2+ uniporter inhibitor)	Rat	24 h	↓ Mitocondrial dysfunction
OP-4183 (PGI2 analogue)	Rat	24 h	↓ Oxidative stress
SAM (ATP precursor)	Rat	24 h	↓ Oxidative stress
Trifluoperazine (calmodulin inhibitor)	Dog	24 h	↓ Microcirculatory dysturbances
Sodium nitroprusside (NO donor)	Rat	24, 48 h	↓ Microcirculatory dysturbances
E5880 (PAF antagonist)	Pig	8 h	↓ Microcirculatory dysturbances
FR167653 (p38 inhibitor)	Rat	30 h	↓ Microcirculatory dysturbances
EGF, IGF-1, NGF-α	Pig	18 h	↑ ATP
LY294002 (PI3K inhibitor)	Rat	3, 7, 9, 24 h	↓ Apoptosis
IDN-1965 (caspase inhibitors)	Rat	24, 30 h	↓ Apoptosis
8br-cAMP and 8br-cGMP (nucleotide analogs)	Rat	24 h	↓ NFα and neutrophil accumulation,
GSNO (NO donor)	Rat	48 h	↓ SEC damage
Pifithrin-alpha (p53 inhibitor)	Rat	24, 48 h	↓ Apoptosis
OP-4183 (PGI2 analogue)	Rat	24 h	↓ Oxidative stress
Tauroursodeoxy-cholate	Rat	2 h	↓ Endoplasmic reticulum stress