Review Article
The Current State of Knowledge of Hepatic Ischemia-Reperfusion
Injury Based on Its Study in Experimental Models
Table 3
Gene therapy to protect liver againts ischemia/reperfusion. Heme oxygenase-1, HO-1; interleukin-13, IL-13; small interference RNA, siRNA; superoxide dismutase, SOD; tumour necrosis factor TNF.
| Gene therapy | Liver transplantation and warm hepatic ischemia | Drug | Specie | Experimental model | Ischemic time | Effect |
| Bag-1 (adenoviral transfer) | Rat | Liver transplantation | 24 h | ↓ TNFα, ↓neutrophil infiltration, ↓ microcirculatory disturbances | Bcl-2 gene (adenoviral transfer) | Rat | Liver transplantation | 16 h | ↓ Apoptosis | Cu/Zn-SOD gene (adenoviral transfer) | Rat | Liver transplantation | 24 h | ↓ Oxidative stress | HO-1 gene (adenoviral transfer) | Rat | Liver transplantation | 4 h | ↓ Macrophage infiltration, ↓ apoptosis | IL-13 (adenoviral transfer) | Rat | Liver transplantation | 24 h | ↓ Proinflammatory cytokines, ↓ liver neutrophil recruitment | Adiponectin (siRNA) | Rat | Warm ischemia | 1 h | ↓ Oxidative stress | ASMase (siRNA) | Mice | Warm ischemia + hepatectomy | 90 min | ↓ Ceramide, ↓ apoptosis | Caspase 3 (siRNA) | Mice | Warm ischemia | 90 min | ↓ Apoptosis | Caspase 8 (siRNA) | Mice | Warm ischemia | 90 min | ↓ Apoptosis | SOD gene (adenoviral transfer) | Rat | Warm ischemia | 1 h | ↓ Oxidative stress | IL-13 (adenoviral transfer) | Rat | Warm ischemia | 30 min | ↓ Proinflammatory cytokine, ↓ neutrophil recruitment |
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