The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models

Table 3

Gene therapy to protect liver againts ischemia/reperfusion. Heme oxygenase-1, HO-1; interleukin-13, IL-13; small interference RNA, siRNA; superoxide dismutase, SOD; tumour necrosis factor TNF.

Gene therapy
Liver transplantation and warm hepatic ischemia
Drug	Specie	Experimental model	Ischemic time	Effect
Bag-1 (adenoviral transfer)	Rat	Liver transplantation	24 h	↓ TNFα, ↓neutrophil infiltration, ↓ microcirculatory disturbances
Bcl-2 gene (adenoviral transfer)	Rat	Liver transplantation	16 h	↓ Apoptosis
Cu/Zn-SOD gene (adenoviral transfer)	Rat	Liver transplantation	24 h	↓ Oxidative stress
HO-1 gene (adenoviral transfer)	Rat	Liver transplantation	4 h	↓ Macrophage infiltration, ↓ apoptosis
IL-13 (adenoviral transfer)	Rat	Liver transplantation	24 h	↓ Proinflammatory cytokines, ↓ liver neutrophil recruitment
Adiponectin (siRNA)	Rat	Warm ischemia	1 h	↓ Oxidative stress
ASMase (siRNA)	Mice	Warm ischemia + hepatectomy	90 min	↓ Ceramide, ↓ apoptosis
Caspase 3 (siRNA)	Mice	Warm ischemia	90 min	↓ Apoptosis
Caspase 8 (siRNA)	Mice	Warm ischemia	90 min	↓ Apoptosis
SOD gene (adenoviral transfer)	Rat	Warm ischemia	1 h	↓ Oxidative stress
IL-13 (adenoviral transfer)	Rat	Warm ischemia	30 min	↓ Proinflammatory cytokine, ↓ neutrophil recruitment