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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 305964, 8 pages
Quantitative Proteomic (iTRAQ) Analysis of 1st Trimester Maternal Plasma Samples in Pregnancies at Risk for Preeclampsia
1Department of Biomedicine, University Women's Hospital, 4031 Basel, Switzerland
2Biozentrum, University of Basel, 4056 Basel, Switzerland
3Laboratory for Prenatal Medicine, Department of Biomedicine, University Women's Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
Received 31 May 2011; Revised 26 December 2011; Accepted 28 December 2011
Academic Editor: Saulius Butenas
Copyright © 2012 Varaprasad Kolla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. C. Hogan, K. J. Foreman, M. Naghavi et al., “Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5,” The Lancet, vol. 375, no. 9726, pp. 1609–1623, 2010.
- B. Jim, S. Sharma, T. Kebede, and A. Acharya, “Hypertension in pregnancy: a comprehensive update,” Cardiology in Review, vol. 18, no. 4, pp. 178–189, 2010.
- E. A. Steegers, “Pre-eclampsia,” The Lancet, vol. 376, no. 9741, pp. 631–644, 2010.
- M. Silasi, B. Cohen, S. A. Karumanchi, and S. Rana, “Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia,” Obstetrics and Gynecology Clinics of North America, vol. 37, no. 2, pp. 239–253, 2010.
- S. Y. Kim, H. M. Ryu, J. H. Yang et al., “Maternal serum and amniotic fluid inhibin A levels in women who subsequently develop severe preeclampsia,” Journal of Korean Medical Science, vol. 21, no. 3, pp. 452–456, 2006.
- S. Y. Kim, H. M. Ryu, J. H. Yang et al., “Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia,” Journal of Korean Medical Science, vol. 22, no. 5, pp. 873–877, 2007.
- K. Spencer, N. J. Cowans, and A. Stamatopoulou, “ADAM12s in maternal serum as a potential marker of pre-eclampsia,” Prenatal Diagnosis, vol. 28, no. 3, pp. 212–216, 2008.
- R. Akolekar, A. Syngelaki, J. Beta, R. Kocylowski, and K. H. Nicolaides, “Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia,” Prenatal Diagnosis, vol. 29, no. 12, pp. 1103–1108, 2009.
- A. Khalil, N. J. Cowans, K. Spencer, S. Goichman, H. Meiri, and K. Harrington, “First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk,” Prenatal Diagnosis, vol. 29, no. 8, pp. 781–789, 2009.
- K. Spencer, N. J. Cowans, and K. H. Nicolaides, “Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia,” Prenatal Diagnosis, vol. 28, no. 1, pp. 7–10, 2008.
- E. R. Norwitz, “Defective implantation and placentation: laying the blueprint for pregnancy complications,” Reproductive BioMedicine Online, vol. 13, no. 4, pp. 591–599, 2006.
- M. Blumenstein, M. T. McMaster, M. A. Black et al., “A proteomic approach identifies early pregnancy biomarkers for preeclampsia: novel linkages between a predisposition to preeclampsia and cardiovascular disease,” Proteomics, vol. 9, no. 11, pp. 2929–2945, 2009.
- P. L. Ross, Y. N. Huang, J. N. Marchese et al., “Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents,” Molecular and Cellular Proteomics, vol. 3, no. 12, pp. 1154–1169, 2004.
- P. K. Chong, C. S. Gan, T. K. Pham, and P. C. Wright, “Isobaric tags for relative and absolute quantitation (iTRAQ) reproducibility: implication of multiple injections,” Journal of Proteome Research, vol. 5, no. 5, pp. 1232–1240, 2006.
- X. Song, J. Bandow, J. Sherman et al., “iTRAQ experimental design for plasma biomarker discovery,” Journal of Proteome Research, vol. 7, no. 7, pp. 2952–2958, 2008.
- V. Kolla, P. Jenö, S. Moes et al., “Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ),” Journal of Biomedicine & Biotechnology, vol. 2010, Article ID 952047, 10 pages, 2010.
- R. D. Unwin, A. Pierce, R. B. Watson, D. W. Sternberg, and A. D. Whetton, “Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells,” Molecular and Cellular Proteomics, vol. 4, no. 7, pp. 924–935, 2005.
- J. E. Elias and S. P. Gygi, “Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry,” Nature Methods, vol. 4, no. 3, pp. 207–214, 2007.
- I. V. Shilov, S. L. Seymourt, A. A. Patel et al., “The paragon algorithm, a next generation search engine that uses sequence temperature values sequence temperature values and feature probabilities to identify peptides from tandem mass spectra,” Molecular and Cellular Proteomics, vol. 6, no. 9, pp. 1638–1655, 2007.
- H. Mi, N. Guo, A. Kejariwal, and P. D. Thomas, “PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways,” Nucleic Acids Research, vol. 35, no. 1, pp. D247–D252, 2007.
- A. Glen, C. S. Gan, F. C. Hamdy et al., “ITRAQ-facilitated proteomic analysis of human prostate cancer cells identifies proteins associated with progression,” Journal of Proteome Research, vol. 7, no. 3, pp. 897–907, 2008.
- C. S. Gan, K. C. Poh, K. P. Trong, and P. C. Wright, “Technical, experimental, and biological variations in isobaric tags for relative and absolute quantitation (iTRAQ),” Journal of Proteome Research, vol. 6, no. 2, pp. 821–827, 2007.
- M. W. Mosesson, “Fibrinogen and fibrin structure and functions,” Journal of Thrombosis and Haemostasis, vol. 3, no. 8, pp. 1894–1904, 2005.
- N. E. Kirschbaum, M. W. Mosesson, and D. L. Amrani, “Characterization of the γ chain platelet binding site on fibrinogen fragment D,” Blood, vol. 79, no. 10, pp. 2643–2648, 1992.
- C. Benoit, J. Zavecz, and Y. Wang, “Vasoreactivity of Chorionic Plate Arteries in Response to Vasoconstrictors Produced by Preeclamptic Placentas,” Placenta, vol. 28, no. 5-6, pp. 498–504, 2007.
- M. M. G. Leeflang, J. S. Cnossen, J. A. M. van der Post, B. W. J. Mol, K. S. Khan, and G. ter Riet, “Accuracy of fibronectin tests for the prediction of pre-eclampsia: a systematic review,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 133, no. 1, pp. 12–19, 2007.
- L. Anton, D. C. Merrill, L. A. A. Neves et al., “Activation of local chorionic villi angiotensin II levels but not angiotensin (1–7) in preeclampsia,” Hypertension, vol. 51, no. 4, pp. 1066–1072, 2008.
- E. L. Skornicka, N. Kiyatkina, M. C. Weber, M. L. Tykocinski, and P. H. Koo, “Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production,” Cellular Immunology, vol. 232, no. 1-2, pp. 144–156, 2004.
- K. R. Atkinson, M. Blumenstein, M. A. Black et al., “An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia,” Journal of Lipid Research, vol. 50, no. 1, pp. 71–80, 2009.
- V. Lange, P. Picotti, B. Domon, and R. Aebersold, “Selected reaction monitoring for quantitative proteomics: a tutorial,” Molecular Systems Biology, vol. 4, article no. 222, 2008.
- P. Picotti, B. Bodenmiller, L. N. Mueller, B. Domon, and R. Aebersold, “Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics,” Cell, vol. 138, no. 4, pp. 795–806, 2009.