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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 346761, 7 pages
http://dx.doi.org/10.1155/2012/346761
Review Article

Advancement in the Development of Models for Hepatitis C Research

1Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA
2Center for Orphan Autoimmune Disorders, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
3Department of Infectious Diseases and Pathology, University of Florida, 2015 SW 16th Avenue, Gainesville, Florida 32608-00881, USA

Received 18 January 2012; Accepted 2 April 2012

Academic Editor: Andrea Vecchione

Copyright © 2012 Wendy C. Carcamo and Cuong Q. Nguyen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatitis C virus (HCV) is a pandemic disease affecting an estimated 180 million individuals worldwide and infecting each year another ~3-4 million people making HCV a global public health issue. HCV is the main cause for chronic hepatitis, cirrhosis, and hepatocellular carcinoma. In the United States, HCV-related chronic liver disease is a leading cause of liver transplantation. Despite significant improvements in antiviral drugs, only ~50% of treated patients with HCV have viral clearance after treatment. Showing unique species specificity, HCV has a narrow range of potential hosts infecting only chimpanzees and humans. For decades, the chimpanzee model has been the only and instrumental primate for studying HCV infection; however, availability, economic, and ethical issues make the chimpanzee an unsuitable animal model today. Thus, significant research has been devoted to explore different models that are suitable in studying the biology of the virus and application in the clinical research for developing efficient and tolerable treatments for patients. This review focuses on experimental models that have been developed to date and their findings related to HCV.